Children’s Health

Type 1 diabetes (T1D) is an autoimmune disease in which a misdirected immune system gradually destroys healthy pancreatic islet β cells, resulting in a lack of insulin. The exact cause of T1D remains unknown. However, β cell-reactive autoantibodies can be detected in circulating blood months to years before diagnosis, raising the possibility of intervening to
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Children with documented child protection concerns are four times as likely to die before they reach their 16th birthday, according to confronting new research from the University of South Australia. The world first study identifies the extreme seriousness of familial child abuse and neglect, measuring for the first time the excess risk of death that
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A new global study of 30-day outcomes in children and adolescents with COVID-19 found that while death was uncommon, the illness produced more symptoms and complications than seasonal influenza. The study, “30-day outcomes of Children and Adolescents with COVID-19: An International Experience,” published online in the journal Pediatrics, also found significant variation in treatment of
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Therapy based on the Nintendo® Wii Balance Board can help improve balance in children with cerebral palsy, according to an analysis published in Developmental Medicine & Child Neurology. For the analysis, researchers from the University of Jaén, in Andalusia, Spain examined data from all relevant randomized controlled trial published to date. In 11 trials with
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A study published in the journal Pediatrics shows the combination of two early reading programs had positive effects on preschool students entering kindergarten in Cincinnati Public Schools over a three-year period. The two early reading programs are: https://www.cincinnatichildrens.org/service/r/reach-out-and-read“>Reach Out and Read, through which children receive a new book and guidance about reading at home during
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The rate of Kawasaki disease in South Korea has substantially decreased during the COVID-19 pandemic, possibly due to pandemic prevention efforts, such as mask-wearing, hand-washing and physical distancing, according to new research published today in the American Heart Association’s flagship journal Circulation. Kawasaki disease is the most common cause of heart disease that develops after
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Researchers at Children’s Hospital of Philadelphia (CHOP) have developed a proof-of-concept treatment for blood disorders like sickle cell disease and beta-thalassemia that could raise hemoglobin levels by activating production of both fetal and adult hemoglobin. Using a viral vector engineered to reactivate fetal hemoglobin production, suppress mutant hemoglobin, and supply functional adult hemoglobin, the researchers
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A study of over 59,000 Icelandic adolescents by a team of Icelandic and North American behavioral and social scientists found that COVID-19 has had a significant, detrimental impact on adolescent mental health, especially in girls. The study is the first to investigate and document age- and gender-specific changes in adolescent mental health problems and substance
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ADHD medications may lower suicide risk in children with hyperactivity, oppositional defiance and other behavioral disorders, according to new research from the Lifespan Brain Institute (LiBI) of Children’s Hospital of Philadelphia (CHOP) and the University of Pennsylvania. The findings, published today in JAMA Network Open, address a significant knowledge gap in childhood suicide risk and
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Researchers at Columbia University Mailman School of Public Health and Universidade Federal de Ciências da Saúde de Porto Alegre, Brazil found that when health workers were trained to promote infant healthy feeding practices to pregnant women their children consumed less fats and carbohydrates at 3 years of age and had lower measures of body fat
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Pregnant women have a higher risk of developing severe coronavirus disease 2019 (COVID-19) if they are infected by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The effect on the fetus, however, is less clear. A new bioRxiv* preprint research paper reports the immunological footprint in the newborn left by maternal infection with SARS-CoV-2 during
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Children’s Hospital Los Angeles has been awarded a $2 million grant from the state of California to study a precision medicine approach to screening children for adverse childhood experiences. The three-year grant–part of the California Initiative to Advance Precision Medicine–was announced by the Governor’s Office of Planning and Research, in partnership with the Office of
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Affecting more than one in a hundred children, autism spectrum disorder is one of the most common neurodevelopmental disorders. It has a particular impact on social interaction, including difficulties in understanding other people’s perspectives, beliefs, desires and emotions, known as ‘theory of mind’. Bilingual families with an autistic child often tend – and are sometimes
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Scientists have revealed a potential mechanism for how traumatic brain injury leads to neurodegenerative diseases, according to a study in fruit flies, and rat and human brain tissue, published today in eLife. The results could aid the development of treatments that halt the progression of cell damage after brain injury, which can otherwise lead to
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